| First Author | Weller PA | Year | 1990 |
| Journal | Proc Natl Acad Sci U S A | Volume | 87 |
| Issue | 15 | Pages | 5667-71 |
| PubMed ID | 2116004 | Mgi Jnum | J:10655 |
| Mgi Id | MGI:59102 | Doi | 10.1073/pnas.87.15.5667 |
| Citation | Weller PA, et al. (1990) Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A 87(15):5667-71 |
| abstractText | We have determined the complete sequence of human vinculin, a cytoskeletal protein associated with cell-cell and cell-matrix junctions. Comparison of human and chicken embryo vinculin sequences shows that both proteins contain 1066 amino acids and exhibit a high level of sequence identity (greater than 95%). The region of greatest divergence falls within three 112-amino acid repeats spanning residues 259-589. Interestingly, nematode vinculin lacks one of these central repeats. The regions of human vinculin that are N- and C-terminal to the repeats show 54% and 61% sequence identity, respectively, to nematode vinculin. Southern blots of human genomic DNA hybridized with short vinculin cDNA fragments indicate that there is a single vinculin gene. By using a panel of human-rodent somatic cell hybrids, the human vinculin gene was mapped to chromosome 10q11.2-qter. |
