| First Author | Zhang Z | Year | 2017 |
| Journal | Leukemia | Volume | 31 |
| Issue | 2 | Pages | 403-413 |
| PubMed ID | 27451973 | Mgi Jnum | J:239428 |
| Mgi Id | MGI:5828719 | Doi | 10.1038/leu.2016.201 |
| Citation | Zhang Z, et al. (2017) A novel slug-containing negative-feedback loop regulates SCF/c-Kit-mediated hematopoietic stem cell self-renewal. Leukemia 31(2):403-413 |
| abstractText | The stem cell factor (SCF)/c-Kit pathway has crucial roles in controlling hematopoietic stem cell (HSC) renewal. However, little is known about the intracellular regulation of the SCF/c-Kit pathway in HSCs. We report here that Slug, a zinc-finger transcription repressor, functions as a direct transcriptional repressor of c-Kit in HSCs. Conversely, SCF/c-Kit signaling positively regulates Slug through downstream c-Myc and FoxM1 transcription factors. Intriguingly, c-Kit expression is induced by SCF/c-Kit signaling in Slug-deficient HSCs. The balance between Slug and c-Kit is critical for maintaining HSC repopulating potential in vivo. Together, our studies demonstrate that Slug functions in a novel negative-feedback regulatory loop in the SCF/c-Kit signaling pathway in HSCs. |
