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Protein Coding Gene : Fbxl4 F-box and leucine-rich repeat protein 4
Primary Identifier  MGI:2140367 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  269514
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrial intermembrane space and nuclear speck. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4).
PHENOTYPE: Homozygous knockout is mostly pre-weaning lethal but, in surviving mice around 1 year of age, increases mitochondrial turnover, causing weight loss and other morphological and also behavioral changes. [provided by MGI curators]
  • synonyms:
  • AI836810,
  • FBL4,
  • F-box and leucine-rich repeat protein 4,
  • Fbxl4,
  • FBL5,
  • expressed sequence AI836810
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Trail: ProteinCodingGene

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