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Protein Domain : Protein of unknown function DUF3827

Primary Identifier  IPR024606 Type  Family
Short Name  DUF3827
description  The function of the proteins in this entry is not currently known, but one of the human proteins () has been implicated in pilocytic astrocytomas [, , ]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase activity and is capable of transforming cells.
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20 Protein Domain Regions

Trail: ProteinDomain




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