| First Author | Hsiao YH | Year | 2012 |
| Journal | Neurobiol Dis | Volume | 45 |
| Issue | 3 | Pages | 1111-20 |
| PubMed ID | 22227002 | Mgi Jnum | J:182319 |
| Mgi Id | MGI:5315216 | Doi | 10.1016/j.nbd.2011.12.031 |
| Citation | Hsiao YH, et al. (2012) Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model. Neurobiol Dis 45(3):1111-20 |
| abstractText | Epidemiological study reveals that socially isolated persons have increased risk of developing Alzheimer's disease (AD). Whether this risk arises from an oxidative stress is unclear. Here we show that N-acetylcysteine (NAC), an anti-oxidant, is capable of preventing social isolation-induced accelerated impairment of contextual fear memory and rundown of hippocampal LTP in 3-month old APP/PS1 mice. Increased hippocampal levels of gamma-secretase activity, Abeta-40 and Abeta-42 seen in the isolated APP/PS1 mice were reduced by chronic treatment of NAC. In addition, social isolation-induced increase in calpain activity and p25/p35 ratio concomitant with decrease in membrane-associated p35 and p35/Cdk5 activity was normalized by NAC. NAC pretreatment also reversed isolation-induced decrease in GluR1 Ser831 phosphorylation, surface expression of AMPARs and p35-GluR1-CaMKII interactions. These results suggest that NAC decreases gamma-secretase activity resulting in the attenuation of Abeta production, calpain activity and conversion of p35 to p25 which stabilized p35-GluR1-CaMKII interactions and restored GluR1 and GluR2 surface expression. Our results indicate that NAC is effective in mouse models of AD and has translation potential for the human disorder. |
