| Primary Identifier | MGI:1330275 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 14764 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). PHENOTYPE: Mice homozygous for a knock-out allele show enhanced IL-5 production and eosinophil recruitment into the lung in an allergic airway inflammatory model. In contrast, mice homozygous for a second knock-out allele exhibit lower serum IgE levels and reduced IgE-mediated inflammatory responses in skin. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
