Primary Identifier | MGI:3575407 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Map1b |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | 20.5 kb of sequence including codons 96-2389, comprising exons 3-5 and part of exon 6, were deleted upon the insertion of a neomycin resistance cassette. Transcripts containing exon 5 sequences were not found in analysis of mutants, and both heavy and light chain polypeptides were absent from immunoblots of mutants. Also absent were any truncated amino-terminal proteins encoded by exons 1 or 2. |