| First Author | Reed KR | Year | 2004 |
| Journal | Oncogene | Volume | 23 |
| Issue | 55 | Pages | 8992-6 |
| PubMed ID | 15480419 | Mgi Jnum | J:94711 |
| Mgi Id | MGI:3513724 | Doi | 10.1038/sj.onc.1208143 |
| Citation | Reed KR, et al. (2004) PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23(55):8992-6 |
| abstractText | Based on recent reports that peroxisome proliferator-activated receptor delta (PPARdelta) activation promotes tumourigenesis, we have investigated the role of this protein in Apc-mediated intestinal tumourigenesis. We demonstrate that the inactivation of Apc in the adult small intestine, while causing the expected nuclear accumulation of beta-catenin, does not cause the expected increase in PPARdelta mRNA or protein but conversely, the levels of PPARdelta mRNA and protein are lowered. Furthermore, we find that ApcMinPPARdelta-null mice exhibit an increased predisposition to intestinal tumourigenesis. Our data suggest that PPARdelta is not directly regulated by beta-catenin, and that inhibition of PPARdelta activity is unlikely to be an appropriate strategy for the chemoprevention or chemotherapy of intestinal malignancies. |
