| First Author | Streicher J | Year | 2000 |
| Journal | Nat Genet | Volume | 25 |
| Issue | 2 | Pages | 147-52 |
| PubMed ID | 10835627 | Mgi Jnum | J:62548 |
| Mgi Id | MGI:1859077 | Doi | 10.1038/75989 |
| Citation | Streicher J, et al. (2000) Computer-based three-dimensional visualization of developmental gene expression. Nat Genet 25(2):147-52 |
| abstractText | A broad understanding of the relationship between gene activation, pattern formation and morphogenesis will require adequate tools for three-dimensional and, perhaps four-dimensional, representation and analysis of molecular developmental processes. We present a novel, computer-based method for the 3D visualization of embryonic gene expression and morphological structures from serial sections. The information from these automatically aligned 3D reconstructions exceeds that from single-section and whole-mount visualizations of in situ hybridizations. In addition, these 3D models of gene-expression patterns can become a central component of a future developmental database designed for the collection and presentation of digitized, morphological and gene-expression data. This work is accompanied by a web site (http://www.univie.ac.at/GeneEMAC). |
