Primary Identifier | MGI:5295641 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Gata1*V205G)1Mym |
Strain of Origin | (C57BL/6 x DBA/2)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This transgene consists of the murine Gata1 cDNA with a V205G (GTG to GGG) mutation under the control of the Gata1 genomic locus spanning 3.9 kb 5' of the hematopoietic IE exon to the second exon (GATA-1 HRD) which recapitulates endogenous Gata1 gene expression. The valine 205 to glycine substitution has been shown to reduce Zfpm1 (Fog-1) association. Five lines were made. This line is a high-expressing line. |