| First Author | Zhang D | Year | 2017 |
| Journal | Nat Med | Volume | 23 |
| Issue | 9 | Pages | 1036-1045 |
| PubMed ID | 28759052 | Mgi Jnum | J:254804 |
| Mgi Id | MGI:6103550 | Doi | 10.1038/nm.4375 |
| Citation | Zhang D, et al. (2017) D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med 23(9):1036-1045 |
| abstractText | D-mannose, a C-2 epimer of glucose, exists naturally in many plants and fruits, and is found in human blood at concentrations less than one-fiftieth of that of glucose. However, although the roles of glucose in T cell metabolism, diabetes and obesity are well characterized, the function of D-mannose in T cell immune responses remains unknown. Here we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation, and increased the proportion of Foxp3(+) regulatory T cells (Treg cells) in mice. In vitro, D-mannose stimulated Treg cell differentiation in human and mouse cells by promoting TGF-beta activation, which in turn was mediated by upregulation of integrin alphavbeta8 and reactive oxygen species generated by increased fatty acid oxidation. This previously unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopathology. |
