| First Author | Chao JL | Year | 2021 |
| Journal | Cell Rep Med | Volume | 2 |
| Issue | 9 | Pages | 100399 |
| PubMed ID | 34622236 | Mgi Jnum | J:320866 |
| Mgi Id | MGI:6880645 | Doi | 10.1016/j.xcrm.2021.100399 |
| Citation | Chao JL, et al. (2021) Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Cell Rep Med 2(9):100399 |
| abstractText | Immune suppression by CD4(+)FOXP3(+) regulatory T (Treg) cells and tumor infiltration by CD8(+) effector T cells represent two major factors impacting response to cancer immunotherapy. Using deconvolution-based transcriptional profiling of human papilloma virus (HPV)-negative oral squamous cell carcinomas (OSCCs) and other solid cancers, we demonstrate that the density of Treg cells does not correlate with that of CD8(+) T cells in many tumors, revealing polarized clusters enriched for either CD8(+) T cells or CD4(+) Treg and conventional T cells. In a mouse model of carcinogen-induced OSCC characterized by CD4(+) T cell enrichment, late-stage Treg cell ablation triggers increased densities of both CD4(+) and CD8(+) effector T cells within oral lesions. Notably, this intervention does not induce tumor regression but instead induces rapid emergence of invasive OSCCs via an effector T cell-dependent process. Thus, induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC. |
