| First Author | Peters T | Year | 2002 |
| Journal | Mamm Genome | Volume | 13 |
| Issue | 4 | Pages | 186-8 |
| PubMed ID | 11956760 | Mgi Jnum | J:76079 |
| Mgi Id | MGI:2178509 | Doi | 10.1007/s00335-001-2142-7 |
| Citation | Peters T, et al. (2002) The mouse Fused toes ( Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster. Mamm Genome 13(4):186-8 |
| abstractText | As a result of transgenic insertional mutagenesis, heterozygous Fused toes ( Ft) mice display a syndactyly of forelimbs and a thymic hyperplasia. Homozygous Ft/Ft embryos die in midgestation, exhibiting a deformation of craniofacial structures, a syndactyly and a polydactyly of fore- and hindlimbs, a disorganization of the ventral spinal cord, and defects in left-right axis formation. Here we report on our structural analyses of the Ft mutation. We established a physical as well as a gene map of the Ft locus, showing that the transgene integration resulted in a deletion of 1.6 Mb of genomic sequences on mouse Chromosome 8. Owing to this deletion, six genes, including the entire IroquoisB ( IrxB) gene cluster, are directly affected by the Ft mutation. |
