| Primary Identifier | MGI:1918954 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 71704 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including bone marrow; enteric nervous system; forelimb bud; liver; and testis. Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3). PHENOTYPE: Mice homozygous for one null allele exhibit increased mean platelet volume and a mild delay in platelet recovery in response to thrombocytopenia. Mice homozygous for another null allele display enhanced muscle regeneration and resistance to age-related decline in muscle function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
