Primary Identifier | MGI:1314633 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 13421 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables endonuclease activity. Involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Acts upstream of or within apoptotic DNA fragmentation and programmed cell death involved in cell development. Located in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1 like 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired necrosis-associated internucleosomal DNA fragmentation. [provided by MGI curators] |