Primary Identifier | MGI:1929701 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 56307 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human METAP2 (methionyl aminopeptidase 2). PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality around E8.5, smaller size, failure to gastrulate, reduced cell proliferation and absence of a distinct mesoderm. [provided by MGI curators] |