| First Author | van Gaalen MM | Year | 2012 |
| Journal | Neurosci Lett | Volume | 510 |
| Issue | 1 | Pages | 58-61 |
| PubMed ID | 22260793 | Mgi Jnum | J:182311 |
| Mgi Id | MGI:5315208 | Doi | 10.1016/j.neulet.2012.01.004 |
| Citation | van Gaalen MM, et al. (2012) NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance. Neurosci Lett 510(1):58-61 |
| abstractText | The Nogo-66 receptor (NgR1) is part of a co-receptor complex on neurons that transmits a signal for inhibition of neurite outgrowth. In addition, NgR1 function has also been related to other disorders such as schizophrenia and Alzheimer's disease. Here, we studied the effect of life-long deletion of NgR1 (ngr(-/-)) in tests for cognition and positive symptoms of schizophrenia. In the water maze, ngr(-/-) mice learned to locate the hidden platform as well as wild type mice, although with slower acquisition. Deletion of NgR1 did not affect amphetamine- or phencyclidine (PCP)-induced hyperactivity, two models of positive symptoms of schizophrenia. Taken together, ngr(-/-) animals show slower acquisition of a spatial learning and memory task. |
