| Primary Identifier | MGI:109275 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 21848 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including p53 binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in protein catabolic process; protein ubiquitination; and regulation of protein stability. Acts upstream of or within several processes, including calcium ion homeostasis; regulation of gene expression; and regulation of signal transduction. Located in cytoplasm; male germ cell nucleus; and perichromatin fibrils. Part of euchromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TRIM24 (tripartite motif containing 24). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased hepatocyte ploidy and uncontrolled hepatocellular proliferation; most adult mice develop malignant hepatocellular carcinomas. Homozygosity for p.C52A + p.C55A or p.S1043A mutations alleviates diet-induced hepatic steatosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
