| First Author | Cooke HJ | Year | 2002 |
| Journal | Nat Rev Genet | Volume | 3 |
| Issue | 10 | Pages | 790-801 |
| PubMed ID | 12360237 | Mgi Jnum | J:79958 |
| Mgi Id | MGI:2429334 | Doi | 10.1038/nrg911 |
| Citation | Cooke HJ, et al. (2002) Mouse models of male infertility. Nat Rev Genet 3(10):790-801 |
| abstractText | Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility. |
