| Primary Identifier | MGI:97759 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 19085 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in modulation of chemical synaptic transmission and regulation of synaptic vesicle cycle. Acts upstream of or within learning or memory. Located in multivesicular body. Part of cAMP-dependent protein kinase complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). PHENOTYPE: Homozygous null mice have reduced LTD and LTP in specific CNS tracts, but normal neuroanatomy and behavior. Response to pain after inflammation is reduced, concurrent with decreased plasma extravasation during the inflammatory response. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
