| First Author | Rechavi G | Year | 1982 |
| Journal | Nature | Volume | 300 |
| Issue | 5893 | Pages | 607-11 |
| PubMed ID | 6292737 | Mgi Jnum | J:49661 |
| Mgi Id | MGI:1278310 | Doi | 10.1038/300607a0 |
| Citation | Rechavi G, et al. (1982) Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element. Nature 300(5893):607-11 |
| abstractText | The cellular oncogene c-mos is rearranged in a mouse myeloma and the tumour mRNA contains transcripts hybridizing with a v-mos probe. The rearranged gene (rc-mos) was cloned in lambda phage and shown to transform mouse fibroblasts in transfection assays, rc-mos differs from its progenitor, c-mos, only at the 5' end of the gene, where c-mos sequences have been substituted by a novel cellular DNA fragment. This fragment contains a 159-base pair (bp) insertion sequence (IS)-like element localized immediately 5' to the junction with c-mos. This is the first demonstration in a non-virally-induced tumour of activation of a cellular oncogene by a mechanism possibly involving DNA transposition. |
