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Protein Coding Gene : Nrip1 nuclear receptor interacting protein 1

Primary Identifier  MGI:1315213 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  268903
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables several functions, including histone deacetylase binding activity; nuclear retinoid X receptor binding activity; and transcription coregulator activity. Involved in circadian regulation of gene expression; lipid storage; and ovarian follicle rupture. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of histone deacetylase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in CAKUT and osteoporosis. Orthologous to human NRIP1 (nuclear receptor interacting protein 1).
PHENOTYPE: Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected. Male and female mice are smaller than wild-type littermates. [provided by MGI curators]
  • synonyms:
  • MGI:1925132,
  • expressed sequence AA959574,
  • AW456757,
  • 8430438I05Rik,
  • MGI:2146638,
  • 6030458L20Rik,
  • RIKEN cDNA 8430438I05 gene,
  • AA959574,
  • Nrip1,
  • MGI:2146368,
  • RIP140,
  • expressed sequence AW456757,
  • MGI:1918801,
  • nuclear receptor interacting protein 1,
  • RIKEN cDNA 6030458L20 gene

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

5 Involved In Mutations

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0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

9 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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0 Driver For