| Primary Identifier | MGI:2442836 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 237911 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable 5'-3' DNA helicase activity and chromatin binding activity. Acts upstream of or within reciprocal meiotic recombination; seminiferous tubule development; and spermatogenesis. Predicted to be located in cytoplasm; nuclear membrane; and nucleoplasm. Predicted to be part of BRCA1-B complex. Predicted to be active in nucleus. Is expressed in brain ventricular layer; cochlea; and rest of cerebellum marginal layer. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Orthologous to human BRIP1 (BRCA1 interacting helicase 1). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit gonadal atrophy, subfertility, germ cell attrition, epithelial tumor predisposition, increased cellular sensitivity to interstrand crosslink-inducing agents, hypersensitivity to replication inhibitors, and predisposition to lymphoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
