| Primary Identifier | MGI:1097686 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 15078 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Involved in oocyte maturation. Acts upstream of or within several processes, including constitutive heterochromatin formation; negative regulation of chromosome condensation; and osteoblast differentiation. Located in Barr body. Part of chromatin and inner kinetochore. Is active in chromosome, centromeric region. Is expressed in several structures, including central nervous system; gonad; heart; hemolymphoid system gland; and retina. Orthologous to human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B). PHENOTYPE: Homozygous mutants for a hypomorphic gene trap allele display partial neonatal lethality, reduced fertility, growth abnormalities and neuromuscular defects. Mice homozygous for a reporter allele exhibit reduced body size and male fertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
