| First Author | Fujisawa K | Year | 1998 |
| Journal | Arthritis Rheum | Volume | 41 |
| Issue | 1 | Pages | 101-9 |
| PubMed ID | 9433875 | Mgi Jnum | J:134112 |
| Mgi Id | MGI:3785019 | Doi | 10.1002/1529-0131(199801)41:1<101::AID-ART13>3.0.CO;2-L |
| Citation | Fujisawa K, et al. (1998) Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice. Arthritis Rheum 41(1):101-9 |
| abstractText | OBJECTIVE. To examine T cell clonotypes infiltrating into arthritic joints and to investigate whether human T cell leukemia virus type I (HTLV-I) env-pX gene products act as autoantigens in HTLV-I env-pX transgenic mice. METHODS. Complementary DNA (cDNA) encoding the V-D-J (third complementarity-determining region [CDR3]) region of T cell receptor beta chain was amplified by Vbeta family polymerase chain reaction. T cell clonotypes were detected by a single-strand conformational polymorphism method, and sequence analysis of the CDR3 region was performed. RESULTS. Distinct oligoclonal T cell expansion was observed in arthritic joints, and a conserved amino acid motif in the CDR3 region was found in T cells infiltrating joints. Moreover, several intraarticular T cells recognized HTLV-I Env and Tax proteins. CONCLUSION. Our results suggest that HTLV-I Env and Tax proteins act as autoantigens that are recognized by autoreactive T cells in inflamed arthritic lesions in the HTLV-I env-pX transgenic mouse. Thus, some T cells infiltrating the joint recognize Env or Tax protein. These cells may trigger chronic arthritis in HTLV-I env-pX transgenic mice. |
