| First Author | Seoane J | Year | 2004 |
| Journal | Cell | Volume | 117 |
| Issue | 2 | Pages | 211-23 |
| PubMed ID | 15084259 | Mgi Jnum | J:235266 |
| Mgi Id | MGI:5795826 | Doi | 10.1016/s0092-8674(04)00298-3 |
| Citation | Seoane J, et al. (2004) Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117(2):211-23 |
| abstractText | FoxO Forkhead transcription factors are shown here to act as signal transducers at the confluence of Smad, PI3K, and FoxG1 pathways. Smad proteins activated by TGF-beta form a complex with FoxO proteins to turn on the growth inhibitory gene p21Cip1. This process is negatively controlled by the PI3K pathway, a known inhibitor of FoxO localization in the nucleus, and by the telencephalic development factor FoxG1, which we show binds to FoxO-Smad complexes and blocks p21Cip1 expression. We suggest that the activity of this network confers resistance to TGF-beta-mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells. |
