| First Author | Deltour S | Year | 1998 |
| Journal | Biochim Biophys Acta | Volume | 1443 |
| Issue | 1-2 | Pages | 230-2 |
| PubMed ID | 9838134 | Mgi Jnum | J:55573 |
| Mgi Id | MGI:1338663 | Doi | 10.1016/s0167-4781(98)00219-x |
| Citation | Deltour S, et al. (1998) The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. Biochim Biophys Acta 1443(1-2):230-2 |
| abstractText | HIC-1 (hypermethylated in cancer), a new candidate tumor suppressor gene located in 17p13.3, encodes a protein with five Kruppel-like C2H2 zinc finger motifs and a N-terminal protein-protein interaction domain called BTB/POZ. These two domains appeared as the only conserved regions found between human HIC-1 and its avian homologue, gammaFBP-B, isolated as a transcriptional repressor of the gammaF-Crystallin gene. We have recloned the HIC-1 gene and found four nucleotide differences within the 3' part of its published coding sequence. The corrected HIC-1 C-terminal end exhibits now significant homology (70%) to the chicken gammaFBP-B C-terminal end and appears thus as a third phylogenetically conserved domain that may serve an important, yet unknown function in HIC-1. |
