| First Author | Babay BE | Year | 2004 |
| Journal | Infect Immun | Volume | 72 |
| Issue | 8 | Pages | 4603-11 |
| PubMed ID | 15271920 | Mgi Jnum | J:92344 |
| Mgi Id | MGI:3052411 | Doi | 10.1128/IAI.72.8.4603-4611.2004 |
| Citation | Babay BE, et al. (2004) Inbred strains derived from feral mice reveal new pathogenic mechanisms of experimental leishmaniasis due to Leishmania major. Infect Immun 72(8):4603-11 |
| abstractText | Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistance to a secondary parasite challenge. The immunological responses showed a TH2 dominance characterized by an early peak of interleukin-4 (IL-4) and IL-13. However, neutralization of IL-4, which leads to a resistance phenotype in BALB/c mice, has no effect on disease progression in MAI mice. Mice of strain PWK develop a protracted but self-healing disease, characterized by a mixed TH1-plus-TH2 pattern of immune responses in which IL-10 plays an aggravating role, and acquire resistance to a secondary challenge. These features are close to those observed in human cutaneous leishmaniasis due to L. major and make PWK mice a suitable model for the human disease. |
