| First Author | Park J | Year | 2015 |
| Journal | Cell Rep | PubMed ID | 25753425 |
| Mgi Jnum | J:228187 | Mgi Id | MGI:5705475 |
| Doi | 10.1016/j.celrep.2015.02.024 | Citation | Park J, et al. (2015) M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARbeta/delta Activation in Tumor Myeloid Cells, Leading to Tumor Progression. Cell Rep |
| abstractText | We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARbeta/delta activity in myeloid cells in vitro and in vivo. Myeloid cell-specific knockout of PPARbeta/delta results in impaired growth of implanted tumors, and this is restored by adoptive transfer of wild-type myeloid cells. We find that IL-10 is a downstream effector of PPARbeta/delta and facilitates tumor cell invasion and angiogenesis. This observation is supported by the finding that the CD11b(low)IL-10(+) pro-tumoral myeloid cell is scarcely detected in tumors from myeloid-cell-specific PPARbeta/delta knockout mice, where vessel densities are also decreased. Fatty acid synthase (FASN) is shown to be an upstream regulator of PPARbeta/delta in myeloid cells and is induced by M-CSF secreted from tumor cells. Our study gives insight into how cancer cells influence myeloid stromal cells to get a pro-tumoral phenotype. |
