| Primary Identifier | IPR029482 | Type | Domain |
| Short Name | HRXXH |
| description | Proteins containing this domain are putative peptidases closely related to the M35 family (). In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these fungal proteins is unknown. Proteins containing this domain include members of the Zps1 (Zinc- and pH-regulated Surface protein) family []. Some of them are fungal allergens; including Asp f2, a major allergen from Aspergillus fumigatus, which reacts with serum from patients with ABPA (allergic bronchopulmonary aspergillosis) [], and pH-regulated antigen 1 (PRA1) from Candida albicans, which has a role in fungal morphogenesis and perhaps in the host-parasite interaction during candidal infection []. |
