| Primary Identifier | MGI:1351330 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 27220 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable neuropeptide hormone activity. Involved in several processes, including adult feeding behavior; negative regulation of appetite; and negative regulation of bone resorption. Acts upstream of or within regulation of bone remodeling. Located in extracellular space. Is expressed in several structures, including adrenal gland; craniocervical region bone; lung; nervous system; and retina. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CARTPT (CART prepropeptide). PHENOTYPE: Homozygous null mice exhibit increases in food consumption, body weight, and fat mass when fed a high-fat diet, but not on a regular diet. Mice homozygous for another disruption in this gene have increased body weight at older ages, impaired insulin secretion and glucose intolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
