| Primary Identifier | MGI:2443665 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 101706 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including disordered domain specific binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of BMP signaling pathway; and positive regulation of keratinocyte differentiation. Acts upstream of or within lung epithelial cell differentiation. Located in several cellular components, including lateral cell cortex; mitotic spindle pole; and nuclear matrix. Is expressed in several structures, including 1st branchial arch mandibular component; brain ventricular layer; early embryo; facial prominence; and oocyte. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). PHENOTYPE: Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
