| Primary Identifier | IPR024162 | Type | Family |
| Short Name | Adaptor_Cbl |
| description | Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface, including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. There are three Cbl related proteins knownto date: Cbl, CblB, and CblC/Cbl3 []. Cbls function as ubiquitin E3 ligase proteins, accepting ubiquitin from specific E2 ubiquitin-conjugating enzymes and transferring it to substrates, promoting their degradation []or endocytosis []. |
