| Primary Identifier | MGI:4829975 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Scn1b |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 was replaced with one in which a C to G transversion (C387G) results in the amino acid substitution of tryptophan for cysteine at position 121 (C121W), mimicking a mutation found in some genetic epilepsy with febrile seizures plus (GEFS+) patients. A loxP was inserted upstream of the modified exon 3. A floxed neo cassette inserted downstream of the modified exon was removed by cre mediated recombination. The modified exon 3 remains floxed. |
