| First Author | Li SH | Year | 1996 |
| Journal | Clin Exp Pharmacol Physiol | Volume | 23 |
| Issue | 3 | Pages | 236-40 |
| PubMed ID | 8934614 | Mgi Jnum | J:33797 |
| Mgi Id | MGI:81274 | Doi | 10.1111/j.1440-1681.1996.tb02602.x |
| Citation | Li SH, et al. (1996) Suppressive effects of a herbal formula, TBL-1, on type II collagen-induced arthritis in DBA/1J mice. Clin Exp Pharmacol Physiol 23(3):236-40 |
| abstractText | 1. The effects of a formula of traditional Chinese medicine, TBL-1, on collagen-induced arthritis (CIA) were investigated in DBA/1J mice. 2. From 4 weeks after the first immunization with bovine type II collagen (CII), TBL-1 or indomethacin was administered orally for 13 weeks. 3. Clinical scores of CIA were decreased by both TBL-1 and indomethacin intervention compared with the control CII-immunized group. 4. Radiographic scores of phalangeal destruction were markedly improved by TBL-1 intervention (P < 0.001), but indomethacin failed. 5. The suppressive effects of TBL-1, but not indomethacin, were manifested in reduced serum anti-CII antibody titres (P < 0.001). 6. These findings suggest that TBL-1 may play a role in regulating some immune responses in the present arthritis model. |
