| First Author | Yamashita A | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 9 | Pages | 1299-303 |
| PubMed ID | 23542032 | Mgi Jnum | J:195510 |
| Mgi Id | MGI:5484703 | Doi | 10.1016/j.febslet.2013.03.024 |
| Citation | Yamashita A, et al. (2013) Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. FEBS Lett 587(9):1299-303 |
| abstractText | The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show that knockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein alphaB-crystallin (alphaBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, alphaBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23 plays a protective role against UVC by accumulating alphaBC in the close vicinity of the ER. |
