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Allele : Cd28<tm1Jmg> CD28 antigen; targeted mutation 1, Jonathan M Green

Primary Identifier  MGI:3722546 Allele Type  Targeted
Attribute String  Not Specified Gene  Cd28
Transmission  Germline Strain of Origin  129X1/SvJ
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting vector was designed to insert alanine substitutions for prolines 187 and 190 in exon 4 (P187A, P190A), thereby disrupting the motif responsible for interaction with SH3 domain-containing proteins. A floxed neo was included with the vector and subsequently removed via cre mediated recombination.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • CD28-AYAA,
  • CD28-AYAA
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

15 Publication categories

Trail: Allele