| First Author | Newman LS | Year | 1995 |
| Journal | Cell | Volume | 82 |
| Issue | 5 | Pages | 773-83 |
| PubMed ID | 7671305 | Mgi Jnum | J:52144 |
| Mgi Id | MGI:1336265 | Doi | 10.1016/0092-8674(95)90474-3 |
| Citation | Newman LS, et al. (1995) Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell 82(5):773-83 |
| abstractText | We have identified a target antigen in autoimmune cerebellar degeneration, beta-NAP, that is closely related to the beta-adaptin and beta-COP coat proteins. Beta-NAP is a nonclathrin-associated phosphoprotein expressed exclusively in neurons, from E12 through adulthood. Beta-NAP is present in the neuronal soma and nerve terminal as soluble and membrane-bound pools and is associated with a discrete set of nerve-terminal vesicles. These results establish beta-NAP as a neuron-specific vesicle coat protein. We propose a model in which beta-NAP mediates vesicle transport between the soma and the axon terminus and suggest that beta-NAP may represent a general class of coat proteins that mediates apical transport in polarized cells. |
