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Protein Coding Gene : Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Primary Identifier  MGI:1098272 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  24014
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in cerebellum; embryo; hippocampus; retina inner nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L).
PHENOTYPE: Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA E230029I04 gene,
  • 2-5A-dependent RNAase,
  • MGI:2445191,
  • E230029I04Rik,
  • ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent),
  • Rnasel

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For