| Primary Identifier | MGI:96086 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 15242 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within several processes, including forebrain development; hepaticobiliary system development; and leukocyte differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis and cardiac development. Mice homozygous for another knock-out allele exhibit embryonic lethality, fetal lethality and abnormal nervous system development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
