| First Author | Reis LF | Year | 1994 |
| Journal | EMBO J | Volume | 13 |
| Issue | 20 | Pages | 4798-806 |
| PubMed ID | 7957048 | Mgi Jnum | J:21235 |
| Mgi Id | MGI:69259 | Doi | 10.1002/j.1460-2075.1994.tb06805.x |
| Citation | Reis LF, et al. (1994) Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J 13(20):4798-806 |
| abstractText | The transcription factor interferon regulatory factor 1 (IRF-1) binds tightly to the interferon (IFN)-beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid of functional IRF-1 by targeted gene disruption. As reported by others, IRF-1-deficient mice showed a discrete phenotype: the CD4/CD8 ratio was increased and IFN-gamma-induced levels of macrophage iNO synthase mRNA were strongly diminished. However, type I IFN induction in vivo by virus or double-stranded RNA was unimpaired, as evidenced by serum IFN titers and IFN mRNA levels in spleen, liver and lung. There was also no impairment in the response of type I IFN-inducible genes. Therefore, IRF-1 is not essential for these processes in vivo. |
