Primary Identifier | MGI:5749378 | Allele Type | Spontaneous |
Attribute String | Null/knockout | Gene | Dock8 |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A C-to-T point mutation located in exon 47 results in a premature stop codon at the arginine codon (p.R2034*). This results in reduced levels of mRNA and absence of detectable levels of protein in bone marrow derived dendritic cells from homozygous mice. This mutation was found in mice carrying Nlrp10tm1Seis |