First Author | Schuh M | Year | 2011 |
Journal | Nat Cell Biol | Volume | 13 |
Issue | 12 | Pages | 1431-6 |
PubMed ID | 21983562 | Mgi Jnum | J:180088 |
Mgi Id | MGI:5305386 | Doi | 10.1038/ncb2353 |
Citation | Schuh M (2011) An actin-dependent mechanism for long-range vesicle transport. Nat Cell Biol 13(12):1431-6 |
abstractText | Intracellular transport is vital for the function, survival and architecture of every eukaryotic cell. Long-range transport in animal cells is thought to depend exclusively on microtubule tracks. This study reveals an unexpected actin-dependent but microtubule-independent mechanism for long-range transport of vesicles. Vesicles organize their own actin tracks by recruiting the actin nucleation factors Spire1, Spire2 and Formin-2, which assemble an extensive actin network from the vesicles' surfaces. The network connects the vesicles with one another and with the plasma membrane. Vesicles move directionally along these connections in a myosin-Vb-dependent manner to converge and to reach the cell surface. The overall outward-directed movement of the vesicle-actin network is driven by recruitment of vesicles to the plasma membrane in the periphery of the oocyte. Being organized in a dynamic vesicle-actin network allows vesicles to move in a local random manner and a global directed manner at the same time: they can reach any position in the cytoplasm, but also move directionally to the cell surface as a collective. Thus, collective movement within a network is a powerful and flexible mode of vesicle transport. |