| Primary Identifier | IPR029905 | Type | Family |
| Short Name | Spire1 |
| description | This entry represents Spire1, which belongs to the Spire family. It contains a KIND (kinase noncatalytic C-lobe) domain and four actin-binding WH2 (WASP homology 2) domains []. It acts as an actin nucleation factors []. The structure of Spire has been revealed [, ]. Spire1 is involved in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport []. The mammalian genome encodes two Spir proteins, Spir-1 and Spir-2. In adult tissues, the spir-2 gene shows a rather broad expression pattern, whereas spir-1 is mainly expressed in neuronal cells of the nervous system. Spir-1 may have a role in neural function []. |
