| First Author | Knapp PE | Year | 2009 |
| Journal | Neurosci Lett | Volume | 451 |
| Issue | 2 | Pages | 114-8 |
| PubMed ID | 19110031 | Mgi Jnum | J:146365 |
| Mgi Id | MGI:3837487 | Doi | 10.1016/j.neulet.2008.12.022 |
| Citation | Knapp PE, et al. (2009) Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8 |
| abstractText | Jimpy is a murine mutation in myelin proteolipid protein, leading to premature death of oligodendrocytes and severe central nervous system hypomyelination. Jimpy is a bona fide model of human Pelizaeus-Merzbacher disease. This paper describes a severe reduction in expression of kappa-opioid receptors (KOP) in oligodendrocytes of jimpy mice. A cell-specific reduction of >90% is apparent by 5 days of age. Expression is not reduced in neurons, and mu-opioid receptor expression is normal. Mechanism(s) leading to deficient KOP expression in jimpy mice remain unclear. We speculate that loss of KOP may be related to increased [Ca(2+)](i) and premature death of jimpy oligodendrocytes. |
