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Publication : Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

First Author  Kovanen PE Year  2005
Journal  Int Immunol Volume  17
Issue  8 Pages  1009-21
PubMed ID  15980098 Mgi Jnum  J:104228
Mgi Id  MGI:3611536 Doi  10.1093/intimm/dxh283
Citation  Kovanen PE, et al. (2005) Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int Immunol 17(8):1009-21
abstractText  T lymphocytes play a central role in controlling adaptive immune responses. IL-2 critically regulates both T cell growth and death and is involved in maintaining peripheral tolerance, but the molecules involved in these and other IL-2 actions are only partially known. We now provide a comprehensive compendium of the genes expressed in T cells and of those regulated by IL-2 based on a combination of DNA microarrays and serial analysis of gene expression (SAGE). The newly identified IL-2 target genes include many genes previously linked to apoptosis in other cellular systems that may contribute to IL-2-dependent survival functions. We also studied the mRNA expression of known regulators of signaling pathways for their induction in response to IL-2 in order to identify potential novel positive and/or negative feedback regulators of IL-2 signaling. We show that IL-2 regulates only a limited number of these genes. These include suppressors of cytokine signaling (SOCS) 1, SOCS2, dual-specificity phosphatase (DUSP) 5, DUSP6 and non-receptor type phosphatase-7 (PTPN7). Additionally, we provide evidence that many genes expressed in T cells locate in chromosomal clusters, and that select IL-2-regulated genes are located in at least two clusters, one at 5q31, a known cytokine gene cluster, and the other at 6p21.3, a region that contains genes encoding the tumor necrosis factor (TNF) superfamily members TNF, LT-alpha and LT-beta.
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