| Primary Identifier | MGI:2150016 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 114715 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in several processes, including negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with cytoplasmic vesicle. Is expressed in several structures, including foregut-midgut junction; lung; metanephros; and telencephalon. Human ortholog(s) of this gene implicated in Legius syndrome. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1). PHENOTYPE: Homozygous null mice display increased airway hyperresponsiveness, eosinophilia, a kinked tail, shortened face, impaired spatial learning and memory, and altered CNS transmission. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
