| First Author | Klappacher GW | Year | 2002 |
| Journal | Cell | Volume | 109 |
| Issue | 2 | Pages | 169-80 |
| PubMed ID | 12007404 | Mgi Jnum | J:76061 |
| Mgi Id | MGI:2178490 | Doi | 10.1016/s0092-8674(02)00714-6 |
| Citation | Klappacher GW, et al. (2002) An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109(2):169-80 |
| abstractText | Defining the molecular mechanisms that coordinately regulate proliferation and differentiation is a central issue in development. Here, we describe a mechanism in which induction of the Ets repressor METS/PE1 links terminal differentiation to cell cycle arrest. Using macrophages as a model, we provide evidence that METS/PE1 blocks Ras-dependent proliferation without inhibiting Ras-dependent expression of cell type-specific genes by selectively replacing Ets activators on the promoters of cell cycle control genes. Antiproliferative effects of METS require its interaction with DP103, a DEAD box-containing protein that assembles a novel corepressor complex. Functional interactions between the METS/DP103 complex and E2F/ pRB family proteins are also necessary for inhibition of cellular proliferation, suggesting a combinatorial code that directs permanent cell cycle exit during terminal differentiation. |
