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Publication : A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids.

First Author  Rossi P Year  1992
Journal  Dev Biol Volume  152
Issue  1 Pages  203-7
PubMed ID  1378413 Mgi Jnum  J:1508
Mgi Id  MGI:50035 Doi  10.1016/0012-1606(92)90172-d
Citation  Rossi P, et al. (1992) A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids. Dev Biol 152(1):203-7
abstractText  We have cloned a novel c-kit mRNA of 3.2 kb expressed in postmeiotic male germ cells. This transcript initiates in the genomic region immediately upstream of the exon coding for the second box of the split c-kit tyrosine kinase domain. The open reading frame (ORF) contains 12 novel amino acids in frame with the C-terminal 190 amino acids of the c-kit protein. It lacks therefore the upstream region in the 5.5-kb c-kit mRNA encoding the extracellular and transmembrane domain, the ATP-binding site and the kinase insert domain present in the c-kit protein.
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