Primary Identifier | MGI:106912 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 13733 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within adaptive immune response and signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and liver. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). PHENOTYPE: Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development. [provided by MGI curators] |